Endocrine Abstracts

Objective: Saturated fatty acids (FAs), e.g. stearic acid (SA), induce apoptosis in pancreatic β-cells while unsaturated FAs, e.g. oleic acid (OA) have nearly no detrimental effect. Moreover, unsaturated FAs are capable of inhibiting the pro-apoptotic effect of saturated FAs. Hypoxia is also known to have deleterious effects on β-cell function and viability. In the present study, we have tested the modulatory effect of hypoxia on the effect of FAs on the growth and v...